Mitochondrial Dysfunction in Pulmonary Fibrosis
نویسندگان
چکیده
منابع مشابه
Idiopathic Pulmonary Fibrosis: Aging, Mitochondrial Dysfunction, and Cellular Bioenergetics
At present, the etiology of idiopathic pulmonary fibrosis (IPF) remains elusive. Over the past two decades, however, researchers have identified and described the underlying processes that result in metabolic dysregulation, metabolic reprogramming, and mitochondrial dysfunction observed in the cells of IPF lungs. Metabolic changes and mitochondrial dysfunction in IPF include decreased efficienc...
متن کاملEpithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis
BACKGROUND Epithelial cell death is a major contributor to fibrogenesis in the lung. In this study, we sought to determine the function of mitochondria and their clearance (mitophagy) in alveolar epithelial cell death and fibrosis. METHODS We studied markers of mitochondrial injury and the mitophagy marker, PTEN-induced putative kinase 1 (PINK1), in IPF lung tissues by Western blotting, trans...
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Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human. Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via in...
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there are significant overlaps in clinical, physiological and pathological features of the two diseases, including the mechanisms of bronchial hyperresponsiveness and atopy that drive obstructive phenotypes [7]. Although asthma may progress to chronic irreversible airflow obstruction, changes in reversibility over time are not widely reported [8, 9]. It may be that we require a new taxonomy to ...
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ژورنال
عنوان ژورنال: Annals of the American Thoracic Society
سال: 2017
ISSN: 2329-6933,2325-6621
DOI: 10.1513/annalsats.201705-370aw